Parkinson‘s disease
Conditions
Interventions
individualized tACS group:Individualized tACS intervention
fixed-parameter tACS group:Fixed-parameter tACS intervention
sham-tACS group:sham-tACS intervention
Sponsors
Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for primary Parkinson's disease (UK Brain Bank clinical diagnostic criteria for PD); 2. PD patients with predominant bradykinesia symptoms and no dyskinesia complications; 3. H-Y stages 2-4; 4. 45-75 years old; 5. Stable medication effects for more than 2 weeks without requiring adjustments.
Exclusion criteria
Exclusion criteria: 1. Diagnosis is unclear or suspected to be Parkinson's syndrome; 2. Impaired skin integrity at the scalp electrode placement site; allergic to electrode gel, conductive sponge, or adhesive; 3. History of epilepsy or EEG indicating epileptiform changes; severe cerebral hemorrhage, traumatic brain injury, tumor, infection, or other diseases that may induce epilepsy; currently taking medications that may lower the seizure threshold; 4. Presence of metal or electronic implants in the brain, neck, or heart, such as deep brain stimulators, ventriculoperitoneal shunt devices, vagus nerve stimulators, cardiac pacemakers, cochlear implants, implanted pulse generators, aneurysm clips, stents; 5. Intracranial hypertension, intracranial infection, acute large-area cerebral infarction, and multiple intracranial aneurysms; 6. Severe cardiovascular diseases, especially in patients with cardiac pacemakers or stents, or recent heart attacks; other severe comorbidities such as pulmonary, hepatic, or renal failure; sleep deprivation, alcohol dependence, glaucoma, and retinal detachment; 7. Severe cognitive impairment or visual/hearing impairments that prevent communication and cooperation during examination; 8. Previous or concurrent use of electroconvulsive therapy or vagus nerve stimulation; 9. Currently participating in other clinical trials, or planning to undergo DBS surgery or participate in other clinical trials within the next 12 months; 10. Pregnant women.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Changes in kinematic parameters;Changes in motor function; | — |
Primary
| Measure | Time frame |
|---|---|
| Changes in kinematic parameters; | — |
Countries
China
Contacts
Public ContactBoyan Fang
Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China
Outcome results
None listed