Neonatal catheter-related thrombosis
Conditions
Interventions
Heparin prevention group:The heparin prevention group was given continuous intravenous infusion of heparin at the beginning, with an initial dose of 5-10u/kg?h. APTT was monitored every 24 hours (targ
Low molecular weight heparin prevention group:The low molecular weight heparin prevention group received nadroparin calcium, 0.75 mg/kg, subcutaneously twice a day. Blood was collected 4 hours after a
Sponsors
Fujian Children's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: Newborns diagnosed with congenital heart disease who need to have a CVC catheter placed for the first time after surgery (gestational age >= 37 weeks, birth weight >= 2500g);
Exclusion criteria
Exclusion criteria: Parents refused to participate in the study; there were contraindications to heparin/low molecular weight heparin (such as platelet count 50s, active bleeding, abnormal liver and kidney function [ALT>2 times the upper limit of normal, Cr>1.5mg/dL]); ECMO support or planned secondary surgery was required after surgery; combined with hereditary thrombotic diseases or congenital coagulation factor abnormalities; received other anticoagulant/antiplatelet therapy within 72 hours before or after surgery; had infective endocarditis or sepsis; CVC flushing solution was not normal saline; vasoactive drug infusion was not through the proximal port of the CVC (=5cm from the tip of the catheter) or there was multi-channel mixed infusion (such as vasoactive drugs and nutrient solution sharing the same line).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of catheter-related thrombosis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of bleeding events;Drug-related adverse reactions; | — |
Countries
China
Contacts
Public ContactYirong Zheng
Fujian children’s hospital
Outcome results
None listed