Skip to content

Clinical study of the sequential method for the determination of half effective dose of afentanil in inhibiting the body motion reaction of extracorporeal shock wave lithotripsy with propofo

Clinical study of the sequential method for the determination of half effective dose of afentanil in inhibiting the body motion reaction of extracorporeal shock wave lithotripsy with propofo

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500103313
Enrollment
Unknown
Registered
2025-05-27
Start date
2025-06-01
Completion date
Unknown
Last updated
2025-06-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Calculi in pancreatic duct and bile duct

Interventions

Patients selected for ESWL:Dosing is sequential

Sponsors

Affiliated hangzhou first people's hospital, zhejiang university school of medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.ASA ? or ?; 2.BMI 18~28kg/m^2; 3.Age 18-65 years old; 4.Patients undergoing ESWL?

Exclusion criteria

Exclusion criteria: 1.Pregnant or breastfeeding women and patients (including men) who plan to have a baby within 3 months; 2.There were obvious respiratory and circulatory dysfunction, abnormal blood routine and blood biochemical indexes before operation; 3.Suffering from severe neuropsychiatric diseases; 4.Taking opioids daily for 1 month or intermittently for nearly 3 months; 5.People who are allergic or contraindicated to opioids, propofol, naloxone and other drugs and their drug components; 6.Patients judged to have difficulty managing the respiratory tract: modified Markov score level III and above.

Design outcomes

Primary

MeasureTime frame
Somatokinetic response during surgery;

Secondary

MeasureTime frame
Induction time from administration to BIS < 65, time of operation, time to recovery, and time after operation when subjects reached the standard for leaving the anesthesia recovery room;Heart rate, blood pressure (systolic/diastolic), respiratory rate, blood oxygen saturation (SPO2), and BIS values after the initiation of administration until the end of the procedure after the subjec;Adverse events that occur during surgery;Postoperative visual analogue scale (VAS) score;

Countries

China

Contacts

Public ContactWeiping Lei

Affiliated hangzhou first people's hospital, zhejiang university school of medicine

leiweiping0209@163.com+86 571 5600 5600

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026