Acute Brain Injury
Conditions
Interventions
Conventional extubation group:Routine mask oxygen inhalation after extubation
SEEK Sequential Group:SEEKflex tube core retention followed by sequential oxygenation group
Sponsors
Huai'an First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.The patient is aged between 18-70 years old; 2.Acute brain injury patients (cerebral hemorrhage, stroke, traumatic brain injury, metabolic encephalopathy, etc.) who require endotracheal intubation to maintain airway and expectoration upon admission to the ICU; 3.Has spontaneous breathing; 4.The patient undergoes invasive mechanical ventilation for at least 24 hours; 5.Obtained informed consent and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Pregnant or lactating women; 2.Unable to pass the SBT test; 3.Tracheotomy or death before going offline; 4.Accidental extubation; 5.Concurrent severe lung diseases (such as COPD, pulmonary fibrosis, pulmonary embolism); 6.Merge severe arrhythmia and heart failure; 7.Do not agree to sign the informed consent form; 8.Currently participating in other drug clinical trials or participating in other clinical trials within 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success rate of extubation within 72 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;Oxygenation index;The maximum difference in the partial pressure of carbon dioxide; | — |
Countries
China
Contacts
Public Contactyolanda
Huai'an First People's Hospital
Outcome results
None listed