Lung cancer
Conditions
Interventions
Group E:0.75% ropivacaine 15 ml, diluted to 28 ml esketamine 0.1 mg/kg 2 ml with normal saline
Group D:0.75% ropivacaine 15 ml, diluted to 28 ml dexmedetomidine 1 µg/kg 2 ml with normal saline
Group R:15 ml of 0.75% ropivacaine, diluted to 30 ml with normal saline
Sponsors
The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients undergoing elective thoracoscopic wedge or segmental or lobar resection ; 2.Age 18 ~ 65 years old, BMI <= 30kg / m^2, junior high school education and above ; 3.American Society of Anesthesiologists ( ASA ) grade I-III ; 4.Agree to use intravenous self-controlled analgesia device after operation .
Exclusion criteria
Exclusion criteria: 1.Have a history of severe central nervous system or respiratory diseases ; complicated with severe liver and kidney dysfunction ; 2.Infection at or near the puncture site ; 3.Severe coagulation dysfunction, nerve block contraindications ; 4.Long-term chronic pain or history of opioid dependence ; 5.Allergic to any drug used in the study ; 6.Refractory hypertension or poor control of diabetes ; 7.Depression or other mental disorders requiring antidepressants ; 8.Preoperative heart rate ( HR ) < 50 beats / min with / without cardiac conduction or rhythm abnormalities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of analgesic;Resuscitation room residence time;Chest tube pull-out time;The first ambulation time of patients after operation;Postoperative adverse reaction;Postoperative hospital stay; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain score;The onset time of nerve block;Quality of recovery;intraoperative hemodynamics;Postoperative anxiety and depression score;Patient sedation score;The total amount of opioids used during and after operation;The total amount of propofol used during operation; | — |
Countries
China
Contacts
Public ContactLi Guangming
The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University
Outcome results
None listed