Bleeding after coronary artery bypass grafting
Conditions
Interventions
Postoperative autotransfusion group:Patients in the postoperative autotransfusion group received shed mediastinal blood collected from mediastinal drainage within the first 6 hours after surgery. The
Standard care group:Patients in standard care group had their shed mediastinal blood discarded in accordance with routine clinical practice. Allogeneic RBC transfusion, including the decision to trans
Sponsors
Fuwai Hospital Chinese Academy of Medial Sciences, Shenzhen
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18~70 years; 2. Undergoing isolated CABG (both on-pump and off- pump);
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Concomitant other types of surgery performed simultaneously; 3. Exclusion of patients requiring re-sternotomy for non-hemorrhagic reasons; 4. Preoperative imaging-confirmed pleural effusion; 5. Active malignancy (diagnosed within 6 months before surgery without completion of radical treatment); 6. Contamination or infection risk present before shed blood reinfusion (e.g., chylothorax, mediastinal infection, or purulent secretion); 7. Occurrence of early severe postoperative complications prior to reinfusion (e.g., postoperative re-sternotomy, acute renal failure) or other conditions deemed by the investigator as unsuitable for enrollment (specific reasons to be documented).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Allogeneic RBC transfusion volume postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative allogeneic RBC transfusion rate;Incidence of in-hospital composite complications (renal insufficiency, myocardial infarction, cerebral infarction, deep vein thrombosis, respiratory insufficiency, bloodstream infection) and all-cause mortality.;Health Economic Evaluation; | — |
Countries
China
Contacts
Public ContactHongwen Ji
Fuwai Hospital Chinese Academy of Medial Sciences, Shenzhen
Outcome results
None listed