Burn
Conditions
Interventions
Experimental group:Dexmedetomidine 0.5ug/kg intravenously pumped for 10min + alfentanil 60ug/kg/h continuous pumping administration
Control group:Normal saline intravenously pumped for 10min + alfentanil 60ug/kg/h continuous pumping administration
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Burn patients preparing for burn dressing changes. 2.Patients aged 18-65 years; 3.The burn site of the patient is not limited, the burn depth is ?-? degree, the burn area is between 1-50%. 4.ASA classification I- III. 5.BMI 18.5 ~ 27.9 kg/m^2. 6.Patient or client signs informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of mental illness or impaired consciousness who are unable to cooperate. 2.Patients with severe organ dysfunction (e.g., cardiovascular and cerebrovascular accidents within 3 months, malignant tumors; current severe hepatic and renal insufficiency). 3.Patients with extensive burns with severe infection and shock; and patients with inhalation lung injury undergoing tracheotomy and mechanical ventilation. 4.Patients who are unconscious and have impaired communication. 5.ASA grade IV or patients who cannot survive for more than 24 hours after treatment. 6.Patients who refuse to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximum pain VAS score during burn dressing change; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue scoring;Whether to use oxygen, airway intervention;Verbal Rating Scale;Whether other medications are used for intervention;Total amount of alfentanil application, times and doses of intraoperative alfentanil addition;Blood concentrations of alfentanil;Ramsay Sedation Score (RSS);Patient satisfaction;Vital signs, conscious state, respiratory depression, nausea and vomiting of patients during and after dressing change; | — |
Countries
China
Contacts
Public ContactZhuang Lei
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed