Acute heart failure
Conditions
Interventions
Control group:No intervention
Experimental group:Use Tolvaptan
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Sign the informed consent form and voluntarily cooperate with regular follow-ups; 2. Age > 18 years old; 3. Patients clinically diagnosed with acute decompensated heart failure: (1) Dyspnea at rest or symptoms of dyspnea with mild physical activity (NYHA grade III-IV); (2) Symptoms or signs of congestion (such as sitting breathing, peripheral edema, jugular vein filling, moist rales in the lungs, chest X-ray indicating pulmonary congestion, etc.); (3) NT-proBNP > 450pg/ml(under 50 years old), > 900pg/ml(50-75 years old), > 1800pg/ml(over 75 years old);
Exclusion criteria
Exclusion criteria: 1.Patients allergic to tolvaptan or similar compounds; 2. Install the circulation auxiliary device; 3. Diagnosed with active myocarditis or amyloid cardiomyopathy; 4. Suspected of having reduced circulating blood volume, obstructive hypertrophic cardiomyopathy, or severe aortic valve stenosis; 5. Anuria, urinary disorders caused by urethral stricture, stones, tumors, etc. 6. Systolic blood pressure in the supine position is lower than 90 mmHg(1 mmHg= 0.133 kPa); 7. Any of the following laboratory test values is abnormal: total bilirubin > 2.5 times the upper limit of normal value, serum creatinine > 2.5 times the upper limit of normal value, serum sodium >145 mmol/L, serum potassium >5.5mmoL/L; 8. For other contraindications associated with the use of tolvaptan, refer to the drug instructions; 9. Pregnant women, lactating women, patients who may be pregnant or have pregnancy plans; 10. In addition to the above, the researchers determined that the patients were not suitable to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in body weight from the baseline examination to the 8th day; | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight change rate on the 8th day;24-hour urine output;The readmission rate of heart failure within 3 months; | — |
Countries
China
Contacts
Public ContactLiu Ying
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed