Severe acute pancreatitis
Conditions
Interventions
Acute pancreatitis observation group:None
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old and <= 80 years old; 2. Early pancreatitis participants who meet the diagnostic criteria for AP in the revised 2012 Atlanta guidelines; 3. Onset <= 2 weeks; 4. Participants who are expected to be hospitalized for more than 72 hours.
Exclusion criteria
Exclusion criteria: 1. Refuse to sign the informed consent form; 2. Combine participants with advanced and terminal malignant tumors;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pancreatic Specialty Tests and Scores(Serum Amylase, Serum Lipase, CRP, WBC Count, ALT, AST, Bilirubin, Blood Glucose, Serum Calcium, Serum Creatinine, BUN, Intra-Abdominal Pressure, CTSI, MCTSI, EPIC Score, BISAP Score, Ranson Score, Marshall Score);Inflammatory Evaluation(Temperature (°C), WBC, Absolute Neutrophil Count, Absolute Lymphocyte Count, IL-6, PCT, CRP);Immune Evaluation(Absolute Lymphocyte Count, CD4 (Abs/%), CD8 (Abs/%), CD4/CD8 Ratio, B Cells (Abs/%), NK Cells (Abs/%), Monocytes, Th1/Th2, Blood Cell Count, Reticulocyte Count, Nucleated RBC Count, C3/C4, Immunoglobulins (IgA/IgM/IgG), Tregs, mHLA-DR);Coagulation Evaluation(PLT, PT, APTT, INR, TT, FDP, D-Dimer, PC, PS, vWF, AT?, FIB, TEG, ACT, CR, PF, PIC, t-PAIC, TAT, TM);Endocrine System(Blood/Urine Catecholamines, FT3, FT4, TT3, TT4, ACTH, PTH, Renin, Angiotensin, Aldosterone, Max/Min Blood Glucose, Glucose Variability, HbA1c, Glycated Albumin);Neural Response(5s Sternal Rub,observe the changes before and after:Immediate HR/SBP/DBP/PI Variability Rate [(Post-Stimulus Value - Baseline)/Baseline], 3-Minute HR/BP/PI Recovery Rate [(Post-Stimulus - 3-Min Post-Stimulus)/(Post-Stimulus - Baseline)]);Autonomic Function(Respiratory Rate, HRV, Pupillary Response, Rapid Breathing Test, Breath-Holding Test, Postural Adjustment Test);Biometabolic Indicators(Temperature, Lactate, Free Fatty Acids, ß-Hydroxybutyrate, Albumin, Prealbumin, TG, TC, LDL-C, HDL-C);Organ Function Indicators(BNP, Troponin, CK-MB, Creatinine, GFR, BUN, Serum Cystatin C, TBIL, IBIL, DBIL, ALP, ALT, AST, Albumin, Globulin, PaO2/FiO2);Visualization indicators of Critical Care Ultrasound;Treatment Indicators: Circulatory Support(Vasoactive Drugs (Dopamine, Metaraminol, NE, Epi, Nitroglycerin, Methylene Blue—Duration/Dose); Inotropes (Dobutamine, Cedilanid, Milrinone, Levosimendan—Duration/Dose); Fluid Resuscitation (Volume/Type); IABP/ECMO);Treatment Indicators: Respiratory Support(Mode (Nasal Cannula, HFNC, NIV/IMV), FiO2, Ventilator Paramet | — |
Secondary
| Measure | Time frame |
|---|---|
| Basic and Clinical Information(Age, Gender, Height, Weight, Admission Diagnosis, Underlying Diseases, APACHE II Score, SOFA Score, SIRS Score, GCS Score, SpO2, NBP, ABP, CVP, PI, ICP, Intra-Abdominal Pressure, Intake (IV + Enteral), Urine Output, Ultrafiltration Volume (RRT), Stool Output, GRV, pH, PO2, PCO2, HCO3-, BE, Lactate); | — |
Countries
China
Contacts
Public ContactQing Xia; Wanhong Yin
West China Hospital, Sichuan University
Outcome results
None listed