Degenerative changes of lumbar spine in the elderly
Conditions
Interventions
Group A:30 minutes before the operation, 133mg of bupivacaine liposome was injected at a concentration of 30ml for ultrasound-guided erector spinae block
Before the incision was closed, 133mg of bupivacaine liposome was injected for local infiltration at the incision site.
Group B:30 minutes before the operation, 266 mg of bupivacaine liposome was administered intravenously at a dose of 60 ml under ultrasound guidance for spinal block of the erector spinae muscles.
Sponsors
Jiangsu University Affiliated Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 60 years; 2. Body Mass Index (BMI) 18 - 30 kg/m²; 3. American Society of Anesthesiologists (ASA) classification I - III; 4. Unilateral bilateral-channel endoscopic lumbar interbody fusion under elective general anesthesia (number of surgical segments <= 2); 5. Willing to sign the informed consent form and cooperate actively in the clinical research.
Exclusion criteria
Exclusion criteria: 1. If the patient has a puncture site infection or corresponding anesthesia contraindications, such as oral anticoagulant drugs, hematological disorders related to coagulation, neuromuscular defects at the nerve block site, or abnormal coagulation function; 2. With severe psychological disorders or mental disorders, history of drug or alcohol abuse; 3. Those with a history of allergy to anesthetic drugs; 4. Patients with severe cardiopulmonary dysfunction; 5. Severe liver or kidney dysfunction; 6. History of lumbar spine surgery in the past; 7. Long-term use of analgesic drugs and discontinuation of medication for less than 2 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The total consumption of opioid drugs (in terms of morphine equivalent); | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS pain score;Number of remedial analgesic administrations;Bedtime;Sleep disorders;The dosage of opioid drugs used;Adverse reaction;Pain substances;Inflammatory factors;Postoperative recovery quality; | — |
Countries
China
Contacts
Public ContactJiang Peng
Jiangsu University Affiliated Hospital
Outcome results
None listed