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Relationship Between CFR and Impaired Left Ventricular Myocardial Reactivity in Patients with CMVD: An Applied Study Based on Adenosine/Dipyridamole and Exercise Stress Echocardiography

Relationship Between CFR and Impaired Left Ventricular Myocardial Reactivity in Patients with CMVD: An Applied Study Based on Adenosine/Dipyridamole and Exercise Stress Echocardiography

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500103229
Enrollment
Unknown
Registered
2025-05-27
Start date
2024-04-01
Completion date
Unknown
Last updated
2025-06-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Microvascular Dysfunction

Interventions

CFVR>= 2.5 group:None
CFVR < 2.5 group:None

Sponsors

Fuwai Yunnan Cardiovascular Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Age of 18-80 years; 2.Experience of stable or unstable angina; 3.Absence of obstructive CAD (50%); 5.Adequate imaging quality for conventional echocardiography, adenosine/dipyridamole SE, CFVR measurement, 2D-STE and myocardial work analysis under both rest and peak hyperaemia conditions.

Exclusion criteria

Exclusion criteria: 1.Suffering from acute coronary syndrome; 2.Suffering from malignant arrhythmia; 3.Moderate to severe valve disease; 4.Congenital heart disease or poor echocardiographic image quality.

Design outcomes

Primary

MeasureTime frame
CFR;GWI;GCW;GWW;GWE;GLS;LVEF;—

Secondary

MeasureTime frame
LVESVi;LVEDVi;IVSd;LVPWd;—

Countries

China

Contacts

Public ContactZhao Wanyu, Xiaoli Dong

Fuwai Yunnan Cardiovascular Hospital

1254285493@qq.com+86 176 2263 2962

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026