macrolide-unresponsive Mycoplasma pneumoniae pneumonia in children
Conditions
Interventions
Experimental group A for 8 years old and over:Doxycycline oral with low-dose methylprednisolone IV
Experiment Group A for under 8 years old:Azithromycin with low-dose methylprednisolone
Experiment Group C for under 8 years old:Doxycycline oral
Experiment Group B for under 8 years old:Azithromycin with medium-dose methylprednisolone IV
Experimental group B for 8 years old and over:Doxycycline oral with medium-dose methylprednisolone IV
Sponsors
Children's Hospital,Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
No minimum to 16 Years
Inclusion criteria
Inclusion criteria: 1.MPP diagnostic criteria: A diagnosis can be made based on medical history, clinical symptoms, signs, and imaging findings, as well as meeting one of the following positive laboratory diagnostic criteria: (1) MP antibody titer increases by four times or more during the recovery phase compared to the acute phase; (2) MP culture positive or MP-DNA or RNA positive. 2.Macrolide-unresponsive M. pneumoniae pulmonary (MUMPP) was defined when children with MPP exhibit persistent fever and no improvement or worsening in clinical signs and pulmonary imaging after 72 hours of standard macrolide treatment. 3.The child himself/herself or his/her guardian signs the informed consent to participate in this study;
Exclusion criteria
Exclusion criteria: 1.patients with primary or secondary immune deficiency/dysfunction, congenital heart disease, chronic liver or kidney disease, oncologic disorders, connective tissue disease, chronic lung disease; 2.patients with evidence of mixed infection; 3.patients with incomplete medical records;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| adverse drug reaction;Proportion of refractory Mycoplasma pneumoniae pneumonia; | — |
Secondary
| Measure | Time frame |
|---|---|
| days of fever;Improvement in chest imaging;days of hospitalisation;Improvement of inflammatory indicators; | — |
Countries
China
Contacts
Public ContactMengyao Li
Children's Hospital,Zhejiang University School of Medicine
Outcome results
None listed