None
Conditions
Interventions
EC50 group:The initial target-controlled infusion concentration of remifentanil was 5.0 ng/mL, which was adjusted in a 0.5 ng/mL gradient according to the sequential method. If the intraoperative card
ED50 and ED95 group:The initial target-controlled infusion rate of remifentanil was 0.2 µg/kg/min, and the gradient was adjusted at 0.02 µg/kg/min according to the sequential method. If the intraopera
Sponsors
Shandong Second People's Hospital (Shandong Ear, Nose and Throat Hospital, Shandong Ear, Nose and Throat Research Institute)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age range: 18-65 years old; (2) American Society of Anesthesiologists (ASA) grades I-III; (3) Selective CO2 laser surgery under laryngoscope with a duration of 0.5-1 hour; (4) Plan to undergo general anesthesia; (5) Sign informed consent forms and cooperate with data collection.
Exclusion criteria
Exclusion criteria: (1) Surgical time greater than 1 hour; (2) Preoperative uncontrolled hypertension (SBP>180mmHg) or arrhythmia; (3) Difficult airway assessment; (4) Poor control of hypertension and severe heart disease; (5)BMI=30 kg/m²; (6) History of chronic pain or opioid use; (7) Any other reasons that prevent cooperation with the research, such as language comprehension barriers, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate;Mean arterial pressure;Depth of anesthesia; | — |
Countries
China
Contacts
Public ContactJuan Zhao
Shandong Second People's Hospital (Shandong Ear, Nose and Throat Hospital, Shandong Ear, Nose and Throat Research Institute)
Outcome results
None listed