Multi-drug resistant bacterial infection in recipients of solid organ transplantation
Conditions
Interventions
Elacycline group:NA
BAT Group:NA
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. >=18 years old. 2. Patients who have received solid organ transplants (liver, kidney, lung, heart) in the past and have been treated with at least one type of immunosuppressant for a long time (such as glucocorticoids, calcaren inhibitors, anti-cell proliferation drugs, rapamycin target protein inhibitors, etc.). 3. Infections caused by known or highly suspected multi-drug resistant pathogenic bacteria (MDR). MDR conforms to the definition in the "Chinese Expert Consensus on the Prevention and Control of Nosocomial Infections Caused by Multi-Drug Resistant Bacteria". 4. Combination regimens based on eracycline or BAT are used as first-line treatment regimens. 5. If the combination regimen is based on elacycline, patients in the treatment group need to be treated with elacycline for =4 days. 6. The clinical outcomes of the cases were complete, and the data could meet the requirements for treatment outcome evaluation (clinical outcomes, microbiological outcomes, and comprehensive efficacy evaluation).
Exclusion criteria
Exclusion criteria: 1. Simple urinary tract or intracranial infection. 2. The culture drug sensitivity shows that the microbial pathogen is not sensitive to etracycline (refer to the MIC breakpoint of ChinaCAST).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 30-day all-cause mortality rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical effective rate;30-day infection recurrence rate;Coefficient of variation of tacrolimus blood concentration during treatment;The types and severity of adverse drug reactions; | — |
Countries
China
Contacts
Public ContactJu Chunrong
The Datansha Campus of the First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed