Major Depressive Disorder (MDD)
Conditions
Interventions
SSRIS plus sham iTBS treatment group:Sham coil treatment
SSRIS +iTBS treatment group:Intermittent theta burst stimulation
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1.Participants will be included if they meet the following criteria: Diagnosis of depressive disorder confirmed by two board-certified psychiatrists and alignment with DSM-5 criteria for depressive disorders. A score of >=17 on the 17-item Hamilton Depression Rating Scale (HAMD). 2.Participants must be aged between 18 and 55 years, with both genders included. 3.Antidepressant treatment predominantly employs SSRIs (Selective Serotonin Reuptake Inhibitors) as monotherapy. 4.Participants must demonstrate the ability to adhere to at least one full cycle of iTBS (Intermittent Theta Burst Stimulation) treatment (10-day protocol) and complete all scheduled follow-up assessments.
Exclusion criteria
Exclusion criteria: 1.Participants with significant medical comorbidities, including but not limited to severe hepatic/renal insufficiency, cardiac disease, or malignant neoplasms, will be excluded. 2.Participants with severe traumatic brain injury (TBI), neurological disorders, or severe psychiatric illnesses including but not limited to schizophrenia, hysterical psychosis, bipolar disorder, etc., will be excluded. 3.Participants with a history of alcohol/substance misuse or those receiving polypharmacy involving multiple antidepressants will be excluded. 4.Subjects with any factors that may significantly affect MRI data quality, including but not limited to metal dental prostheses, metallic implants, or body piercings, will be excluded to preclude reliable image acquisition.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depressive symptoms;Resting-State Functional Magnetic Resonance Imaging; | — |
Countries
China
Contacts
Public ContactZhenyu Hu
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed