Acute ST-segment elevation myocardial infarction
Conditions
Interventions
Aspiration thrombectomy group:Aspiration thrombectomy
No aspiration thrombectomy group:None
Sponsors
Changzhou Second People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.The patient presented with symptoms of myocardial ischaemia lasting >=30 min; definite ECG changes suggestive of STEMI: ST-segment elevation of >0.1 mV in adjacent limb leads or >=0.2 mV in adjacent thoracic leads; 2.Received direct PCI treatment: within 12 hours of onset, or 12-24 hours of onset but still with persistent symptoms, haemodynamic instability or fatal arrhythmia; 3.Aged between 18 years and 80 years. 4.High thrombus load: 1). TIMI thrombus grade 3 or 4 on coronary angiography. 2). TIMI thrombus >= grade 3 after guidewire passage or pre-dilatation of the offender's lesion 1.5 mm diameter if the emergency coronary angiogram shows TIMI thrombus grade 5 (TIMI flow grade 0). 5.No grossly tortuous or calcified lesions in the responsible vessel; 6. Informed consent.
Exclusion criteria
Exclusion criteria: 1.contraindications for tirofiban use; 2.prior fibrinolysis; 3.active severe bleeding; 4.history of major surgery < 4 weeks; 5.cardiogenic shock with mechanical ventilation; 6.severe hepatic and renal dysfunction; 7.the presence of previous myocardial infarction or coronary artery bypass grafting; 8.contrain- dications to magnetic resonance imaging, such as implanted pacemakers, defibrillators, or metallic intracranial implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MVO mass;Major adverse cardiovascular events(MACE);Infarct size(IS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Intramyocardial haemorrhage(IMH);Myocardial salvage index (MSI); | — |
Countries
China
Contacts
Public ContactXin Chen
Changzhou Second People's Hospital
Outcome results
None listed