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A randomized controlled study on the clinical efficacy of regenerative pulp therapy in preventing and treating root resorption after replantation of young permanent teeth with complete dislocation

A randomized controlled study on the clinical efficacy of regenerative pulp therapy in preventing and treating root resorption after replantation of young permanent teeth with complete dislocation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500103151
Enrollment
Unknown
Registered
2025-05-26
Start date
2025-06-01
Completion date
Unknown
Last updated
2025-06-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

teeth trauma injury

Interventions

Regenerative dental pulp treatment group:Regenerative endodontic treatment
Apical induction plasty group:Apical induction plasty treatment

Sponsors

Shenzhen Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
6 Years to 16 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged 6 to 16, regardless of gender; 2. Young permanent teeth with at least one necrotic pulp in a single tube: temperature and electrical pulp tests show negative reactions; Imaging evidence shows that the affected tooth is a single tube with a root apex diameter greater than 1 mm; 3. The affected tooth has a history of complete dislocation and replantation trauma; 4. The patient and guardian agree to participate in this clinical study.

Exclusion criteria

Exclusion criteria: 1. The affected tooth is accompanied by root fracture or alveolar bone fracture; 2. Allergic to dental materials such as Vitapex or iRoot BP; 3. The child has poor cooperation or suffers from systemic or chronic diseases that may affect prognosis (including intellectual disabilities and mental disorders).

Design outcomes

Primary

MeasureTime frame
Clinical success rate;

Secondary

MeasureTime frame
Time to improvement of discomfort symptoms;The degree of external root resorption;The number of affected teeth in which the root of the tooth continues to develop;Survival rate;

Countries

China

Contacts

Public ContactChen Chanchan

shenzhen children's hospital

chenchan0609@163.com+86 189 2383 1756

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026