postoperative delirium
Conditions
Interventions
Active stimulation group:The stimulation site is the left dorsolateral prefrontal cortex (DLPFC), specifically the F3 region. One session of iTBS treatment includes three 50Hz pulses, repeated at 5Hz
Sham stimulation group:Sham stimulation (sham coil), the timing and location are the same as the intervention group, routine postoperative analgesia
Sponsors
the Second Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>=60 years, < 90 years; 2. Undergo elective/limited non-cardiac major surgery (operation duration=2 hours, general anesthesia, and expected hospital stay of at least 3 days); 3.ASA I~III level; 4. Voluntarily participate and sign the informed consent form; 5. Complete clinical data, able to complete preoperative questionnaire survey and postoperative follow-up.
Exclusion criteria
Exclusion criteria: 1. Refusal to participate in this study; 2. Inability to communicate due to coma, severe dementia or language impairment before surgery; 3. Preoperative schizophrenia, previous seizures or risk of seizures, Parkinson's disease, myasthenia gravis; 4. Severe heart, brain, kidney, and liver function abnormalities; 5. The skull defect is not repaired; 6. Have a metal or pacemaker implant; 7. Accompanied by other diseases that may affect the indicators of inflammatory response (such as infection, autoimmune diseases, tumors, etc.); 8. Patients with ASA grade IV and/or expected survival <=24h.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium(POD) incidence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of POD;Postoperative sleep quality; Pain;High-sensitivity C-reactive protein (hs-CRP);TNF-a level in peripheral blood; IL-6; IL-1ß; | — |
Countries
China
Contacts
Public ContactWan Xing
The Second Affiliated Hospital of Nanjing Medical University
Outcome results
None listed