Sepsis
Conditions
Interventions
Intervention group:On the basis of standardized treatment, take 10 milligrams of dapagliflozin tablets every day for a total of 5 days
Sponsors
Subei People's Hospital of Jiangsu province
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria 1. Age >=18 years old; 2. For those diagnosed with sepsis within 12 hours of admission to the department, the diagnostic criteria comply with the international diagnostic criteria of SPESI 3.0. 3. Obtain the informed consent form
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. Pregnant or lactating women; 2. Patients with sepsis diagnosed more than 24 hours before admission; 3. With chronic heart disease: (1) with chronic heart failure, NYHA class =3, (2) with moderate to severe mitral and/or aortic valve disease, (3) with chronic cardiomyopathy: hypertrophic cardiomyopathy, dilated cardiomyopathy; 4. With serious complications: terminal stage of malignant tumors; Liver cirrhosis; Diabetic ketoacidosis 5. Specific drugs: current or long-term use of drugs affecting heart function: including ß-blockers (metoprolol, bisoprolol, etc.), positive inotropic drugs (digitalis, digoxin, etc.) 6. Patients with severe renal impairment (eGFR<30 ml/min/1.73m^2) or long-term dialysis 7. Those who took dapagliflozin or other SGLT-2 inhibitors within 12 weeks; 8. Known allergic to any SGLT-2 inhibitor;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sequential Organ Failure Assessment (SOFA) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cytokine;Left ventricular ejection fraction(EF);Mitral valve blood flow ratio (E/A);The ratio of peak E to peak e '(E/e');Hemodynamic parameters;Fasting blood glucose;Apache? score;Renal function indicators;Troponin;Myoglobin;CK-MB;White blood cell;Neutrophil;Procalcitonin;Lactic acid;ICU length of stay;Days of mechanical ventilation;Days of CRRT; | — |
Countries
China
Contacts
Public ContactYu Jiangquan
Subei People's Hospital of Jiangsu province
Outcome results
None listed