None listed
Conditions
Interventions
Oxalidine group:Analgesic Pump Protocol for Total Hysterectomy
Loading Dose: 0.05 mg·kg-1 oliceridine postoperatively .Continuous Infusion Prepare 0.35 mg·kg-1 oliceridine diluted with normal saline t
Sufentanil group:Postoperative Analgesia Pump Protocol for Total Hysterectomy:
Loading Dose:Sufentanil 0.2 µg·kg-1 administered intravenously ,
Continuous Infusion:Prepare sufentanil 2 µg·kg-1 diluted
Sponsors
Anqing Municipal Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Patients scheduled for elective total laparoscopic hysterectomy1; 2) ASA physical status classification I-III2; 3) Age 18-65 years; 4) BMI 18-28 kg/m² with body weight >40 kg1; 5) Compliance with ethical standards and voluntary informed consent signed by participants.
Exclusion criteria
Exclusion criteria: 1?) Severe cardiac, pulmonary, hepatic, or renal dysfunction? ?2) History of psychiatric disorders or long-term use of psychotropic medications?, includes dementia, schizophrenia, chronic analgesic use, alcohol dependence, etc. 3)Patients with severe systemic infections? 4) Communication barriers or neurological dysfunction? 5) Preoperative hypoxemia? 6)Recent participation in other drug trials? within the past 30 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting and movement VAS pain scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart Rate,Systolic Blood Pressure,Diastolic Blood Pressure,Mean Arterial Pressure;Incidence of Postoperative Adverse Events (Nausea ,Somnolenc,Respiratory depression, Pruritus); | — |
Countries
China
Contacts
Public ContactDuan Jinjuan
Anqing Municipal Hospital
Outcome results
None listed