Breast cancer
Conditions
Interventions
Gold Standard:Pathological diagnosis+Immunohistochemistry(IHC)+FluorescenceInSituHybridization(FISH)
Index test:a predictive model was constructed based on the color Doppler ultrasound images of the breast of patients before treatment to non-invasively determine the expression of the HER2 gene in bre
Sponsors
Xiang'an Hospital of Xiamen University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. The expression of HER2 was clear in newly diagnosed women with invasive breast cancer who underwent surgical treatment (HER2(2+) had FISH detection results); 2. Women diagnosed with breast cancer by air-core needle puncture without surgical treatment, HER2(3+) or HER2(2+), and FISH test results were amplified; 3. Pathology reports are clear and searchable; 4. Ultrasound images from tertiary hospitals are available before surgery or puncture, and the images can be exported and the images are clear; 5. Pathology, immunohistochemistry, and in situ hybridization (FISH) tests are performed in qualified laboratories and by qualified and experienced physicians or technicians. 6. The time interval between ultrasound image acquisition and surgery or puncture was less than 3 weeks;
Exclusion criteria
Exclusion criteria: 1. Ipsilateral breast surgery history; 2. History of malignant tumor treatment with radiotherapy and chemotherapy; 3. Pathological findings or clinical data were missing; 4. The ultrasound image data is missing or the image quality is poor; 5. The tumor diameter is large and the image collection is incomplete;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AUC;Sensitivity;Specifcity;Accuracy; | — |
Countries
China
Contacts
Public ContactLi Liangtao
Xiang'an Hospital of Xiamen University
Outcome results
None listed