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Effects of dexamethasone as an adjuvant to ropivacaine in transversus abdominis plane (TAP) on milliequivalents of opioid use and recovery quality after laparoscopic total hysterectomy: A prospective randomized controlled study

Effects of dexamethasone as an adjuvant to ropivacaine in transversus abdominis plane (TAP) on milliequivalents of opioid use and recovery quality after laparoscopic total hysterectomy: A prospective randomized controlled study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500103085
Enrollment
Unknown
Registered
2025-05-23
Start date
2025-06-01
Completion date
Unknown
Last updated
2026-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain following laparoscopic hysterectomy

Interventions

Group A (formal experiment):Transversus abdominis plane block was performed using 0.375% ropivacaine and 0.1 mg/kg dexamethasone.
Group B (formal experiment):Transversus abdominis plane block was performed using 0.375% ropivacaine.
Group A (pre-experiment):Transversus abdominis plane block was performed using 0.375% ropivacaine and 0.1 mg/kg dexamethasone.
Group B (pre-experiment):Transversus abdominis plane block was performed using 0.375% ropivacaine.

Sponsors

The First Affiliated Hospital of Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
35 Years to 64 Years

Inclusion criteria

Inclusion criteria: 1. Patients with a clear diagnosis who need laparoscopic total hysterectomy due to benign indications; 2. Age 35~64 years old, female, BMI18~28kg/m^2; 3. ASA grading I~II; 4. Patient is able to understand the written informed consent form and has the will to sign the document.

Exclusion criteria

Exclusion criteria: 1. Patients with serious diseases of heart, lungs, kidneys and other important organs, metabolic diseases, and chronic pain; 2. Patients with a history of alcohol, anesthetic, or analgesic drug abuse; 3. Having a mental disorder or cognitive impairment and being unable to communicate normally; 4. Those who are allergic to related anesthetic drugs; 5. Use of antiemetics, analgesics, sedatives and antipruritic drugs 24 hours before surgery; 6. Patients who are allergic to non-steroidal anti-inflammatory drugs (NSAIDs) or ropivacaine, bronchial asthma; 7. Patients with long-term use of analgesics (NSAIDs, opioids) or steroid therapy, as well as paresthesias or peripheral neuropathy, and a history of chronic pain.

Design outcomes

Primary

MeasureTime frame
QoR-15 score ;

Secondary

MeasureTime frame
Oral morphine milliequivalents;VAS score;First press time of postoperative PCIA;QoR-15 score ;

Countries

China

Contacts

Public ContactAn Ke

The First Affiliated Hospital of Sun Yat-sen University

anke@mail.sysu.edu.cn+86 158 0003 7306

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 3, 2026