Cerebral Small Vessel Disease
Conditions
Interventions
Sponsors
The Second Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: From January 2024 to December 2025, 500 patients over the age of 40 who underwent cranial MRI detection in the supporting unit were prospectively collected
Exclusion criteria
Exclusion criteria: 1. current acute infectious, inflammatory, or contagious diseases; 2. pulmonary hypertension; 3. acute diabetic complications and vascular complications; 4. hematologic disorders or malignancies (including intracranial tumors); 5. immune system abnormalities or hepatic/renal dysfunction; 6. history of myocardial infarction, stroke, atrial fibrillation, or heart failure; 7. secondary causes of white matter lesions (e.g., carbon monoxide poisoning, metabolic disorders, encephalitis, thyroid dysfunction, multiple sclerosis); 8. severe peripheral vascular disease; 9. pre-existing neurological or psychiatric disorders; 10. inability for self-care; 11. inability to cooperate due to communication impairments; 12. incomplete medical records that may affect model establishment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 25(OH)D;SAA;Interleukin-1 beta;Klotho Beta;Interleukin-6;FGF-21;Prothrombin Fragment 1+2;Asymmetric Dimethylarginine, ADMA;AQP-4;OPG;e-selectin;Recombinant S100 Calcium Binding Protein ß;IL-18;ICM-1;von Willebrand Factor;eNOS; | — |
Secondary
| Measure | Time frame |
|---|---|
| PAI-1;Soluble Interleukin-6 receptor; | — |
Countries
China
Contacts
Public ContactYing Fan
The Second Affiliated Hospital of Harbin Medical University
Outcome results
None listed