Sedative-induced hypoxemia and hypotension
Conditions
Interventions
Cyclopropofol group:Ciprofol
Cyclopropofol and etomidate mixed solution group:Ciprofol and Etomidate Combination Solution
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1: Aged 60-80 years 2: Body mass index (BMI) 18-30 kg/m² 3: ASA physical status I-III 4: Scheduled for combined upper and lower gastrointestinal endoscopy (gastroscopy and colonoscopy), including simple therapeutic procedures such as polypectomy
Exclusion criteria
Exclusion criteria: 1: Refusal to participate 2: BMI >30 kg/m² 3: Allergy to study medications 4: Severe obstructive sleep apnea (AHI >30 events/hour) 5: Acute upper respiratory tract infection, acute asthma exacerbation, or baseline SpO2 180 mmHg or DBP >110 mmHg), unstable angina 7: Active gastrointestinal bleeding with hemodynamic instability, or baseline hypotension (SBP 1 hour 10: Concurrent participation in other clinical trials
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The combined incidence of hypoxemia and hypotension;Incidence of hypotension;Diastolic blood pressure(DBP); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of hypoxemia;Sedation success rate;Endoscopist Satisfaction Score;Myoclonus incidence and severity;Incidence of airway interventions (chin lift, insertion of oral/nasal airway);Incidence of body movement during endoscopy;Dosages of anesthetics;Dosages of vasopressors;Incidence of respiratory depression;Incidence of Severe injection pain;Incidence of Postoperative nausea/vomiting in the post-anesthesia care unit (PACU).;Anesthesiologist Satisfaction Score;Patient Satisfaction Score;Mean Arterial Pressure(MAP);Sedation onset time;Procedure duration;Awakening time;Recovery time;Heart rate(HR);Systolic blood pressure(SBP); | — |
Countries
China
Contacts
Public ContactPingle Li
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed