Upper limb dysfunction (due to amputation)
Conditions
Interventions
Healthy Volunteer Group:Participants will receive functional electrical stimulation (FES) applied to specific fingers as sensory input. During the experiment, participants will be instructed to focus
their electroencephalography (EEG) signals will be recorded synchronously to identify P300 potentials. In the subsequent online prosthesis control testing phase, real-time processed EEG signals will b
Amputee Patient Group: Following phantom limb perception and mapping, patients will receive functional electrical stimulation (FES) applied to specific mapped areas on their stump or, assigned areas a
Sponsors
Department of Mechanical Engineering, Tsinghua University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria include: (A) Healthy subjects: (1) Age 18-60 years; (2) Normal cognitive and motor functions, able to understand and execute experimenter's instructions; (3) Able to understand and voluntarily sign the informed consent form. (B) Patient subjects: (1) Age 18-60 years; (2) At least one upper limb amputation, with the amputation site suitable for prosthesis wearing and operation (e.g., amputation above the wrist or elbow); (3) The patient is willing to use a prosthesis and can cooperate with prosthesis training (able to accept prosthesis wearing and willing to participate in related tasks), or if the patient has not yet worn a prosthesis, is willing to wear it during the experiment and undergo adaptive training; (4) The amputated limb has a stump where phantom limb mapping can be established (e.g., preserved partial stump length, able to perceive or experience phantom limb phenomena); (5) No severe complications, such as cardiovascular disease or severe diabetes, and no other physical diseases or disorders affecting prosthesis use; (6) The patient has no cognitive impairment and is able to understand and follow the experimenter's instructions; (7) Able to understand and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion criteria include: (1) Individuals with severe cognitive impairment, a history of severe mental illness (e.g., severe depression), or inability to understand experimental instructions; (2) Unstable physical condition, or uncontrolled severe underlying diseases (e.g., severe cardiovascular disease, epilepsy, etc.); (3) Skin on the stump or at the intended sites for functional electrical stimulation (e.g., fingers) has damage, severe scars, infection, or severe skin disease, making it unsuitable for electrode placement; (4) Presence of implanted cardiac pacemakers, neurostimulators, or specific types of metal implants (especially in the head or along the stimulation path); (5) Other severe neurological diseases affecting EEG signal recording or the safe execution of tasks; (6) Patients unable to adapt to prosthesis wearing or cooperate with prosthesis training (applicable to patient subjects).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| P300 EEG Signal Classification Accuracy;Online Prosthesis Control Task Success Rate;Online Prosthesis Control Task Completion Time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Characteristics of P300 Event-Related Potentials (ERPs);Subjective Feedback on System Usability and Comfort; | — |
Countries
China
Contacts
Public ContactTianyu Jia
TsingHua University
Outcome results
None listed