Stroke
Conditions
Interventions
Healthy group:None
Cerebellar group:None
Brain group:None
Sponsors
The Third Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Cerebellar group: 1. The selected cases must meet the diagnostic criteria for stroke established by the Cerebrovascular Group of the Chinese Medical Association's Neurology Society in 2019, and be confirmed through cranial CT or MRI to have damage in the cerebellum, with coexisting motor coordination, balance, and fine motor control disorders, ataxia, dysmetria, intention tremor, or nystagmus; 2. First-time onset, with a disease duration <=1 year; 3. Age 18-80 years; 4. Consciousness clear, able to cooperate with physical examination, and without severe cognitive impairment; 5. Patients and their families agree to undergo iTBS testing and sign an informed consent form; 6. Negative pathological reflexes. Brain group: 1. The selected cases must meet the diagnostic criteria for stroke established by the Cerebrovascular Group of the Chinese Medical Association's Neurology Society in 2019, and the location of injury must be confirmed by cranial CT or MRI to be in the cerebral cortex, with no symptoms such as ataxia, dysmetria, intention tremor, or nystagmus; 2. First-time onset, with a disease duration of =1 year; 3. Age between 18 and 80 years; 4. Patients who are conscious and can cooperate with physical examination, without severe cognitive impairment; 5. Patients and their families agree to undergo iTBS testing and sign an informed consent form; 6. Positive pathological reflexes. Healthy group: 1. Healthy male or female subjects aged 18 to 80 years old; 2. Voluntary subjects and signed informed consent; 3. Dominant hand is right.
Exclusion criteria
Exclusion criteria: Cerebellar group: 1. Patients with a history of neurological diseases; 2. Patients wearing a pacemaker, having intracranial metal implants, or with skull defects; 3. Patients and their immediate family members who have been definitively diagnosed with any type of epilepsy, regardless of whether they are currently experiencing an episode or have stopped medication; 4. Patients with severe dysfunction in vital organs such as the heart, lungs, liver, or kidneys, or other serious physical illnesses; 5. Patients with severe cognitive, communication disorders, mood disorders, irritability, or inability to cooperate; 6. Pregnant women; 7. Patients with severe balance disorders or ataxia. Brain group: 1. Patients with a history of neurological diseases; 2. Patients wearing a pacemaker, having intracranial metal implants, or with skull defects; 3. Patients and their immediate family members who have been definitively diagnosed with any type of epilepsy, regardless of whether they are currently experiencing an episode or have stopped medication; 4. Patients with severe dysfunction in vital organs such as the heart, lungs, liver, or kidneys, or other serious physical illnesses; 5. Patients with severe cognitive, communication disorders, mood disorders, irritability, or inability to cooperate; 6. Pregnancy. Healthy group: 1. Age less than 18 years or more than 80 years; 2. High myopia (still affecting normal life even when wearing glasses); 3. Headache and dizziness; 4. Subjects who the investigator considers unsuitable to participate in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer assessment for lower extremity;Modified Rankin Scale; | — |
Countries
China
Contacts
Public ContactKui Li
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed