Lung cancer
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1) Aged 18 to 65 years old; (2) Patients with solid pulmonary nodules undergoing video-assisted thoracoscopic surgery (VATS) or robotic-assisted thoracic surgery (RATS) for lung resection, including pulmonary wedge resection, segmentectomy, and lobectomy; (3) American Society of Anesthesiologists (ASA) physical status classification I–III; (4) Estimated surgical time =6 hours and postoperative hospital stay >= 2 days; (5) Voluntary participation and signed informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with obvious airway anatomical abnormalities unsuitable for laryngeal mask and bronchial blocker use; (2) Body mass index (BMI) >= 30 kg/m^2 or =18.5 kg/m^2; (3) Allergic to any general anesthetic drugs, including propofol, sufentanil, remifentanil, etc.; (4) History of unstable angina, ischemic myocardial infarction, heart failure, or cerebrovascular accident in the past 6 months; (5) Preoperative distant tumor metastasis; (6) Preoperative severe lung diseases (pulmonary fibrosis, severe lung abscess, cor pulmonale; or FEV1 50 mmHg); (7) Poorly controlled hypertension or diabetes mellitus before surgery; (8) History of dementia, psychosis, or other neurological diseases; (9) Patients currently taking sedative medications, antidepressants, or hormones; (10) Patients with chronic pain, alcohol abuse, or drug dependence; (11) Pregnant or lactating patients; (12) Participated in other clinical trials in the past 3 months; (13) Inability to understand Mandarin or Cantonese
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| quality of recovery 15 at 48 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of sore throat within 48 hours postoperatively;HR MAP;The severity of pulmonary atelectasis at the initiation of surgery;The incidence of intraoperative hypoxemia;PPCs;Preoperative and postoperative 30-day QoR-15 scores;Time to first ambulation;Duration of drainage tube placement;Postoperative length of hospital stay; | — |
Countries
China
Contacts
Guangzhou Institute of Cancer Research,the Afliated Cancer Hospital, Guangzhou Medical University