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Exosome-Derived microRNA-143 Promotes Gastric Cancer Progression by Targeting BATF2 and Modulating the Tumor Microenvironment

Exosome-Derived microRNA-143 Promotes Gastric Cancer Progression by Targeting BATF2 and Modulating the Tumor Microenvironment

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500103021
Enrollment
Unknown
Registered
2025-05-23
Start date
2025-05-30
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastric cancer

Interventions

Case group:None
Healthy group:None

Sponsors

Affiliated Hospital of Guangdong Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Voluntary participation and ability to provide informed consent; 2.Tissue biopsy confirmed gastric adenocarcinoma; 3.The postoperative pathology was as follows: the depth of tumor invasion was T1, T2, T3, T4a, and the TNM stages were: stage I, II, and III (according to the TNM staging method for gastric cancer jointly announced by the International Union Against Cancer (UICC) and the American Cancer Federation (AJCC) in 2010); 4.Patients with most distal gastrectomy and D2 lymph node dissection or total gastrectomy and D2 lymph node dissection and radical resection; 5.20 years old<=age<=80 years, BMI18--30 kg/m^2; 6.Have not participated in the clinical trial research of other drugs in the 3 months prior to enrollment.

Exclusion criteria

Exclusion criteria: 1.Non-tumor bleeding, obstruction, perforation, and infectious surgery; 2.Intraoperative and postoperative confirmation that the gastric tumor invades adjacent structures as T4b, or confirmation of peritoneal seeding or distant metastasis of the tumor. 3.Concomitant dysfunction of other important organs: including severe liver and kidney dysfunction; cerebral organic diseases, specifically referring to aneurysmal vascular diseases or arteriovenous malformations and cerebral hemorrhage; severe hypertension, coronary heart disease, cardiac insufficiency (NYHA = Class III), pulmonary arterial hypertension; hematological diseases; coagulation dysfunction; severe respiratory diseases. 4.Diagnosed with autoimmune diseases or having a history of steroid use for more than one month. 5.Patients with alcohol or drug dependence or a history of drug abuse. 6.Patients taking antipsychotic medications. 7.Patients who are deemed unsuitable for inclusion by other researchers.

Design outcomes

Primary

MeasureTime frame
MicroRNA 143;Exosome;

Countries

China

Contacts

Public ContactLin Lin

Affiliated Hospital of Guangdong Medical University

13763042806@163.com+86 759 2387416

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026