Diseases of the digestive system detected by endoscopy
Conditions
Interventions
Group L2:0.35mg oliceridine (5ml from saline) + 1.5-2mg/kg propofol group
Group L3:0.5mg oliceridine (5ml from saline) + 1.5-2mg/kg propofol group
Group C:Equivalent amount of saline 5ml + 1.5-2mg/kg Propofol group
Group L1:0.1mg oliceridine (5ml from saline) + 1.5-2mg/kg propofol group
Sponsors
The Second Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.American Society of Anesthesiologists (ASA) Class I to II; 2.Meet the indications for painless gastroenteroscopy in the 2019 edition of the Chinese Guidelines for Bowel Preparation Related to Gastrointestinal Endoscopy Diagnosis and Treatment; 3.Age 18-65 years; 18 kg/m2 <= BMI <= 30 kg/m^2; 4.Signs were stable and able to undergo painless gastroenteroscopy; 5.Communication without barriers; 6.Voluntary participation and signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Refusal to sign an informed consent form; 2.Severe respiratory depression, acute or severe bronchial asthma; 3.History of acute inflammatory disease of the respiratory tract with no cure within 2 weeks prior to signing informed consent; 4.Known or suspected gastrointestinal obstruction; 5.Known hypersensitivity to the drugs and ingredients used in this study; 6.Severe hepatic, renal, and adrenal insufficiency; 7.Long-term use of opioids; 8.An electrocardiogram suggests an abnormal QT interval; 9.The screening period predicts the likelihood of developing or having a history of difficult airway conditions, such as obstructive sleep apnea syndrome; 10.Participation in other drug trials within three months prior to signing the informed consent form; 11.History of drug and/or alcohol abuse within 1 year prior to signing the informed consent, where alcohol abuse is defined as drinking an average of more than 15 g of alcohol per day (15 g of alcohol is equivalent to 450 ml of beer or 150 ml of wine or 50 ml of light liquor).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time of recovery of orientation;The number of cases of dizziness was recorded;The number of postoperative nausea and vomiting cases was recorded;Record the number of cases of hypotension;The number of cases of injection pain was recorded;Time of induction of anesthesia (extinction of eyelash reflex, loss of consciousness);Time of examination operation;The number of headache occurrences was recorded;Anesthesia recovery time;Record the number of cases of respiratory depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive function;Patient satisfaction ratings;Number of propofol additions and total dose;Hemodynamic parameters: heart rate (HR), blood pressure (MAP), respiratory rate (RR), oxygen saturation (SpO2); | — |
Countries
China
Contacts
Public ContactYu Shuchun
The Second Affiliated Hospital of Nanchang University
Outcome results
None listed