Recurrent urinary tract infections
Conditions
Interventions
Menopausal women with a diagnosis of antibiotic-refractory recurrent urinary tract infection: "Cocktail Therapy"
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Menopausal women with a diagnosis of antibiotic-refractory recurrent urinary tract infection. Diagnostic criteria are: symptomatic urinary tract infection confirmed by at least 3 urine cultures within 1 year or at least 2 urine cultures within 6 months prior to receiving treatment. Urine culture: positive for one known uropathogen >1000 cfu/ml and allergy or resistance to 3 or more antibiotics. Symptoms: at least three lower urinary tract symptoms, including urinary frequency, urgency, dysuria, hematuria, dysuria, and lower abdominal pain.
Exclusion criteria
Exclusion criteria: 1. Known urologic tumors , stones and congenital or acquired genitourinary tract abnormalities; 2.Prolonged indwelling urinary catheter, or neurogenic bladder requiring intermittent catheterization; 3. Residual urine volume >100ml; 4.Uncontrolled diabetes mellitus; 5. Steroidal corticosteroids being applied; 6. Immunosuppressive disease; 7.History of any sex hormone replacement therapy in the previous year; 8.Known or suspected sex hormone-dependent malignancy or any other active malignancy; 9. Unexplained vaginal bleeding; 10. Active or recent thromboembolic disease; 11.Presence of contraindications to sodium hyaluronate infusion; 12. Severe hepatic or renal function abnormalities; 13.Unwillingness to accept treatment, inability to understand the treatment regimen, or refusal to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interval between treatment and 1st relapse (days);Number of recurrences of urinary tract infections during the 1-year follow-up period (times/year); | — |
Secondary
| Measure | Time frame |
|---|---|
| Need for antibiotic therapy during follow-up (drugs and duration);Pelvic pain-urinary urgency-frequent urination ;Quality of Life ; | — |
Countries
China
Contacts
Public ContactDeyi Luo
West China Hospital, Sichuan University
Outcome results
None listed