Disorders of consciousness
Conditions
Interventions
Thalamic group:Left thalamic temporal interference stimulation
Sham stimulus group:None
Sponsors
The Third Affiliated Hospital of Sun Yat sen University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-70 years old; (2) Duration of disease>=4 weeks; (3) impairment of consciousness (e.g., trauma, stroke, ischemic-hypoxic encephalopathy, etc.); (4) Patients diagnosed with unresponsive arousal syndrome (UWS) or microconscious state (MCS) using CRS-R; (5) Vital signs are stable and can complete the research trial; (6) If you use awareness-improving drugs, at least 2 weeks or more, the dose will not be adjusted during the enrollment period; (7) The patient's family members voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Consciousness impairment caused by neurodegenerative diseases, brain tumors and other causes; (2) Combined epilepsy (seizures within 1 month before enrollment); (3) Metal or electronic device implants (e.g., pacemakers, cochlear implants, deep brain stimulators, spinal cord stimulation, aneurysm clips, internal fixation devices after ventriculoperitoneal shunts, etc.); (4) EEG, MRI and PET-CT are contraindicated, and the examination cannot be completed; (5) Other serious diseases that may affect the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coma Recovery Scale - Revised Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement rate;Glass Coma Scale Score;Glasgow Outcome Score;Resting electroencephalogram;Functional magnetic resonance imaging; | — |
Countries
China
Contacts
Public ContactXiquan Hu
The Third Affiliated Hospital of Sun Yat sen University
Outcome results
None listed