moyamoya disease, ischemic cerebrovascular disease
Conditions
Interventions
Healthy controls matched to moyamoya patients by sex, age, and educational level:None
Sponsors
Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. All patients underwent digital subtraction angiography (DSA) and were diagnosed with moyamoya disease (according to the 2012 diagnostic criteria of the Spontaneous Occlusion of the Circle of Willis [Moyamoya Disease] Research Committee of Japan). Additionally, healthy controls matched for gender, age, years of education, and regional background were recruited based on the following criteria. 2. Age: 18–65 years old. 3. Cognitive Screening: Patients with moyamoya disease were screened using the Mini-Mental State Examination (MMSE) to exclude dementia. 4. Neuroimaging: Magnetic resonance imaging (MRI) and computed tomography (CT) were used to exclude significant cerebral hemorrhage or cerebral infarction lesions. 5. Functional & Mental Status: No motor dysfunction or psychiatric disorders, and voluntary participation. 6. Metal Implants: No patients with metal implants (e.g., cardiac pacemakers, cardiac/cerebral stents). 7. Claustrophobia: No history of claustrophobia (to ensure MRI compliance). 8. Mood Disorders: No significant depressive symptoms that could interfere with testing. 9. Informed Consent: Willingness to accept study risks and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Moyamoya syndrome secondary to:(1) Atherosclerosis; (2) Autoimmune diseases (e.g., systemic lupus erythematosus, antiphospholipid antibody syndrome, polyarteritis nodosa, Sjögren’s syndrome); (3) Meningitis; (4) Neurofibromatosis; (5) Intracranial tumors; (6) Down syndrome; (7) Head trauma; (8) Radiation-induced vasculopathy 2.Contraindications for MRI: Metallic implants (e.g., cardiac pacemakers, prosthetic hip joints) 3. Claustrophobia. 4. Motor dysfunction. 5. Large ischemic/hemorrhagic lesions confirmed by CT or MRI. 6. Blood product refusal and hematologic disorder-induced coagulopathy 7. Pregnancy or perinatal status. 8. High-risk candidates unfit for general anesthesia despite preoperative optimization 9. Inability to cooperate or provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative complication rates of MMD patients were recorded, including new-onset cerebral infarction, ischemic attacks, hyperperfusion syndrome, intracranial hemorrhage, seizures, subdural hematoma, and poor wound healing;Short-term outcomes, cognitive status, and neuroimaging findings in MMD patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative and postoperative cerebral hemodynamics of MMD patients ;Neurocognitive and functional neuroimaging correlates in MMD patients;Neurocognitive and functional neuroimaging correlates in healthy controls; | — |
Countries
China
Contacts
Public ContactZhiyong Shi
Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School
Outcome results
None listed