Bronchoscopy is required for diagnosis and treatment of related diseases
Conditions
Interventions
A group:General anesthesia is performed with drugs such as propofol, fentanyl, rocuronium, etc
B group:Ultrasound-guided nerve block and cricothyroid puncture combined with remimazolam
P group:Combination of propofol and esketamine
R group:Combination of remimazolam and esketamine
D group:Combination of dexmedetomidine and esketamine
Sponsors
First affiliated Hospital of Huzhou Normal College
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Part One: 1. general bronchoscopy; Bronchoscopic biopsy, endotracheal endoscopic endoscopic tumor and lymph node biopsy; Endobronchial tumor interventional treatment for trachea, endobronchial stent implantation, balloon dilation; Patients with bronchoscopy for foreign bodies 2. Age 18~80 years old 3. ASA Classification I.-III 4. Body Mass Index (BMI) 18~30kg/m^2 Part Two: 1. Schedule bronchoscopy examination 2. ASA Classification I-II 3. Age 18-65 years old 4. Body Mass Index (BMI) 18-28 kg/m²
Exclusion criteria
Exclusion criteria: Part One: 1. Allergy to anesthetic drugs 2. Severe hypertension and arrhythmia, severe heart and lung dysfunction 3. Newly onset of myocardial infarction, unstable angina pectoris 4. Severe pulmonary hypertension 5. Severe coagulation disorder 6. Multiple bullae 7. Combined aortic aneurysm 8. Mental disorders 9. Refusal of the patient or family to participate Part Two: 1. Resting SpO2 < 93%, preoperative MAP < 60 mmHg, preoperative HR < 50 bpm 2. Severe cardiopulmonary dysfunction and severe hypertension, arrhythmia 3. Patients with severe liver and kidney dysfunction and/or coagulopathy 4. Patients with severe sleep apnea syndrome 5. Patients with potential or confirmed difficult airways 6. Patients with severe mental or cognitive, neurological dysfunction 7. Patients or family members refuse to participate 8. Patients allergic to the study drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vital signs at each time point;Incidence of hypoxemia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Onset of anesthesia;Wake time;Choking reaction;Incidence of hypoxemia;Patient and operating physician satisfaction;Minimum oxygen saturation;Vital signs at each time point;Total amount of esketamine;Number and amount of propofol supplements;Wake time;Incidence of perioperative adverse reactions;Patient and operating physician satisfaction; | — |
Countries
China
Contacts
Public ContactWang Xinqiang
First affiliated Hospital of Huzhou Normal College
Outcome results
None listed