Periorbital wrinkles
Conditions
Interventions
Radiofrequency microneedling combined with mesotherapy group:Radiofrequency microneedling treatment once every 4 weeks, for a total of 3 treatments (at week 0, week 4, and week 8).
Combined with: Meso
Radiofrequency microneedling group:Radiofrequency microneedling treatment once every 4 weeks, for a total of 3 treatments (at week 0, week 4, and week 8).
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
Female
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Female patients aged 35-65 years. 2.Patients have static wrinkles appearing on the periorbital skin, with or without symptoms of aging, laxity and hyperpigmentation. 3.Facial skin is essentially intact, with no significant inflammation, ulceration, or exudation. 4.The severity and distribution of periorbital wrinkles are symmetrical between the left and right eyes, with at least one periorbital area (lateral canthus, infraorbital region, or medial canthus) showing a grade I-II of Fitzpatrick Wrinkle and Elastosis Scale.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of dermal filler treatments or hyaluronic acid-based aesthetic procedures, as well as those who have undergone periocular rejuvenation therapies (e.g., laser, radiofrequency, focused ultrasound) within 6 months prior to enrollment. 2.Patients with a history of oral steroids, collagen, hyaluronic acid, or related cosmetic product use, as well as those taking skin growth-promoting supplements within 3 months prior to enrollment. 3.Patients with traumatic periocular lesions, infections, severe ocular diseases, or severe systemic diseases. 4.Patients with keloid-prone constitution. 5.Patients who are pregnant or in the lactation period. 6.Patients who currently involved in other clinical trial studies. 7.Patients whom the investigator deems unsuitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fitzpatrick Wrinkle and Elastosis Scale Evaluation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Erythema index;Skin thickness;Global Aesthetic Improvement Scale;Antera3D Wrinkles measurement;VISIA imaging;Skin hydration ;Melanin Index;Transepidermal water loss;Skin elasticity; | — |
Countries
China
Contacts
Public ContactFenglin Zhuo
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed