Major Depressive Disorder
Conditions
Interventions
Observation group:None
Sponsors
Beijing Anding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age between 18 and 65 years old, regardless of gender; 2. With education level of primary school or higher; 3.Meet the diagnostic criteria for depression in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5), and the diagnosis is verified by M.I.N.I. 4.Either first episode or recurrence is acceptable, and the total score of HAMD-17 at baseline is >=17 points; 5.Have not received systematic treatment for this episode and plan to receive antidepressant drug treatment; 6. The subject himself/herself signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of bipolar disorder, schizophrenia, depressive episode with psychotic features, or schizoaffective disorder, or organic mental disorder 2.Refractory depression (history of failure of = 2 antidepressant drug treatments in the past); 3.Score of the suicide item in HAMD-17 = 3 points; 4.History of dementia and other neurological diseases that seriously affect cognitive function; 5.History of drug or alcohol dependence within the past 6 months; 6.Received electroconvulsive therapy (ECT) within 3 months before enrollment; 7.Concurrent use of mood stabilizers, antipsychotic drugs, and drugs for the treatment of somatic diseases that affect neuroelectrophysiological indicators; 8.Other situations that the researcher deems inappropriate for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prediction accuracy of the antidepressant efficacy prediction model; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electrophysiological biomarkers that have predictive value for antidepressant efficacy; | — |
Countries
China
Contacts
Public ContactLei Feng
Beijing Anding Hospital, Capital Medical University
Outcome results
None listed