Depressive disorder
Conditions
Interventions
10HZ IF stimulation:10HZ IF stimulation:
10Hz IF stimulation (total 2400 sec):
ramp-up (30 sec) => stimulation (10Hz , 1.6mA channel 1’s electrode pair
2.4mA channel 2’s electrode pair, 4mA total, 2340 sec) => ramp-down (30 sec)
20HZ IF stimulation:20HZ IF stimulation:
20Hz IF stimulation (total 2400 sec):
ramp-up (30 sec) => stimulation ( 10Hz , 1.6mA channel 1’s electrode pair
Sham stimulation :Sham stimulation (total 2400 sec):
Electrodes will be placed on the head in the same locations as IF Intervention
Sponsors
Institute of Psychology of the Chinese Academy of Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) 18-65 years old, regardless of gender; 2) The ability to provide written informed consent prior to the commencement of any research-related proceedings; 3) BDI>10(mild to severe depression) at the time of screening; 4) did not start taking any psychotropic drugs within 4 weeks prior to screening; 5) Able to stick to tasks and interventions; 6) Be able to understand and comply with research requirements as determined by the investigator.
Exclusion criteria
Exclusion criteria: Exclusion Criteria - Patients will be excluded if they: 1. currently take medications that potentially limit the IF efficacy 2. have a non-correctable clinically significant sensory impairment (i.e., cannot hear well enough to cooperate with naturalistic emotion task) 3. have any other condition that, in the opinion of the investigator(s), would adversely affect the subject's ability to complete the study or its measure 4. wear a hairstyle or headdress that prevents electrode contact with the scalp or would interfere with the stimulation (e.g., thick braids , hair weave, afro, wig)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scale Scores change in depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Behavioral data;EEG Signals - Time domain features;EEG Signals - Frequency domain features;EEG Signals - Functional connectivity;Correlation between EEG and depression symptoms;Scale Scores change in anxiety; | — |
Countries
China
Contacts
Public ContactZhiyan Wang
Institute of Psychology of the Chinese Academy of Sciences
Outcome results
None listed