None
Conditions
Interventions
Control group:Propofol
Treatment group:Remimazolam besylate
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >=65 years old; 2.Patients treated with invasive Mechanical Ventilation (excluding tracheotomy); 3.Patients with a sedation target RASS score of -2-0; 4.The duration of tracheal intubation on admission was =24 hours;
Exclusion criteria
Exclusion criteria: 1.High paraplegia, patients admitted to the ICU due to advanced malignancy or its complications; 2.Severe craniocerebral injury, brain tumor, intracranial hypertension, cerebrovascular accident, coma, status epilepticus, etc; 3.Patients with a history of alcohol or substance abuse; 4.High-dose vasoactive agents (norepinephrine >=0.8ug/kg*min) were needed to maintain hemodynamics after adequate fluid resuscitation; 5.Patients who were allergic to study drugs such as remimazolam besylate, propofol and their excipients; 6.Patients for whom informed consent was not obtained; 7.Participate in other clinical drug validation studies; 8.Patients with left ventricular ejection fraction <=40%; 9.Other conditions deemed by the investigator to be ineligible for inclusion;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| During the treatment period, the time without intubation within 7 days in the two groups of patients; | — |
Countries
China
Contacts
Public ContactZhenguo Zeng
The First Affiliated Hospital of Nanchang University
Outcome results
None listed