postoperative delirium
Conditions
Interventions
MCI auricular sham stimulation group:auricular sham stimulation
MCI taVNS group:Auricular vagus nerve stimulation
non-MCI auricular sham stimulation group:auricular sham stimulation
non-MCI taVNS group:Auricular vagus nerve stimulation
MCI cervical sham stimulation group:cervical sham stimulation
MCI tcVNS group:Cervical vagus nerve stimulation
non-MCI cervical sham stimulation group:cervical sham stimulation
non-MCI tcVNS group:Cervical vagus nerve stimulation
Sponsors
Tianjin Third Central Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: American Society of Anesthesiologists physical status II-III patients, aged >=65 year, scheduled for elective surgery under general anesthesia
Exclusion criteria
Exclusion criteria: The patients had a history of neurological diseases or surgery affecting cognitive function, and a history of neuropsychiatric drug and alcohol dependence. Patients with serious diseases of the heart, liver, kidney, respiratory and other systems; Severe hearing or vision impairment and inability to read or speak; Implantation of an electrical stimulation device (pacemaker/defibrillator); Previous surgery or abnormal anatomy of the anterior cervical spine; Patients with inflammation or taking anti-inflammatory drugs; Patients deemed unsuitable for participation in this clinical study by other clinicians
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative cognitive scores; surgery name;infusion quantity;the amount of bleeding;Use of vasoactive agents;Intraoperative blood pressure;Postoperative adverse reactions;eye-opening time;extubation time;PACU stay time;Postoperative recovery time;serum IL-6;serum TNF-a;serum Aß42;serum Aß40; | — |
Countries
China
Contacts
Public ContactHaiyun Wang
Tianjin Third Central Hospital
Outcome results
None listed