Bone and joint diseases
Conditions
Interventions
PRP group:UKA surgery combined with PRP injection
"Cocktail" group:UKA surgery combined with a "cocktail" injection
Usual care group:UKA procedure only
Sponsors
Qianxinan Prefecture People's Hospital
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with knee osteoarthritis diagnosed according to the 2021 edition of the Chinese Guidelines for the Diagnosis and Treatment of Osteoarthritis, whose pathological changes are mainly medial compartments of the knee joint, confirmed by imaging examination as unilateral compartment injury, and the lateral chamber structure is intact, and the patellofemoral joint is not significantly involved or only has mild degenerative changes; 2. Unilateral knee osteoarthritis; 3. Knee range of motion > 90°, flexion contracture =50 years old; 8. Good treatment compliance, agree to participate in this trial and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those with language, cognition, and communication disabilities; 2. Previous history of ipsilateral hip and ankle replacement surgery; 3. Those with degenerative lesions of the contralateral compartment and patellar joint; 4. Those with severe organ dysfunction and uncontrolled infection; 5. Those who have been injected with other drugs in the knee joint cavity in the past 3 months; 6. Allergy to the drug of this study or combined with severe allergic diseases; 7. Patients with blood and endocrine system diseases; 8. Those who have recently received immunosuppressants or anticoagulants and other drugs; 9. Those with mental or consciousness disorders who are unable to cooperate with clinical treatment or examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hospital for special surgery knee score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue scale;Range of motion; | — |
Countries
China
Contacts
Public ContactWu Jun
Qianxinan Prefecture People's Hospital, Xingyi City, Guizhou Province
Outcome results
None listed