Tumor recurrence rate after radical prostatectomy for prostate cancer
Conditions
Interventions
Experimental group:General anesthesia combined with bupivacaine liposome TAP block, with fentanyl added as appropriate during surgery based on the patients response to surgical stimuli
Control group: General anesthesia without combination of bupivacaine liposome TAP block, with intermittent addition of fentanyl as needed during surgery
Sponsors
Huashan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
Male
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Prostate cancer patients voluntarily agree to robot assisted laparoscopic radical prostatectomy; 2.The diagnostic criteria for limited prostate cancer patients undergoing robot assisted laparoscopic radical prostatectomy are determined in accordance with the "Chinese Urology and Andrology Disease Diagnosis and Treatment Guidelines 2022 Edition" published by the Chinese Medical Association; 3.Preoperative prostate biopsy to identify prostate cancer patients; 4.According to the AJCC guidelines for staging recommendations, prostate cancer patients withT=<2, N0M0, and PSA=< 20ng/ml should be selected; 5.Preoperative screening of patients who do not require further treatment after surgery based on imaging examinations and prostate-specific antigen results; 6.Age range from 40 to 75 years old; 7.ASA grade 1-3, without severe complications of important organs such as heart, lung, liver, and kidney; 8.Study participants voluntarily used postoperative analgesia pumps; 9.Research participants voluntarily sign informed consent forms.
Exclusion criteria
Exclusion criteria: 1.Patients who cannot remove the tracheal tube after surgery and are transferred to the ICU; 2.Previous endocrine therapy or chemotherapy; 3.Preoperative imaging examinations (using magnetic resonance imaging to evaluate lymph node and visceral metastasis, and bone scanning to evaluate bone metastasis) indicate bone metastasis, distant lymph node metastasis, and visceral metastasis; 4.Patients with intraoperative blood loss exceeding 800ml.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival time of patients without biochemical recurrence after radical prostatectomy; | — |
Secondary
| Measure | Time frame |
|---|---|
| No imaging progression recurrence rate, perioperative opioid use, incidence of postoperative complications, and all-cause mortality rate of prostate cancer; | — |
Countries
China
Contacts
Public ContactQu Yu
Huashan Hospital Affiliated to Fudan University
Outcome results
None listed