Postpartum depression
Conditions
Interventions
Esketamine group:Following the delivery of the fetus, esketamine was administered at a dose of 0.25 mg/kg mixed in 20 ml of saline via intravenous infusion over a period of 10 minutes. The postoperati
Dexmedetomidine group:Following the delivery of the fetus, dexmedetomidine was administered at a dose of 0.5 ug/kg mixed in 20 ml of saline via intravenous infusion over a period of 10 minutes. The po
Control group:Following the delivery of the fetus, 20 ml of saline via intravenous infusion over a period of 10 minutes. The postoperative intravenous analgesic pump consisted of 100 µg of sufentanil
Sponsors
The First Maternity and Infant Hospital Affiliated to Tongji University
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: Pregnant women aged 20-45 years, at full-term gestation (> 37 weeks), with an Edinburgh Postnatal Depression Scale (EPDS) score > 9, and scheduled to undergo an elective cesarean section under neuraxial anesthesia.
Exclusion criteria
Exclusion criteria: Patients with a history of mental disorders prior to childbirth; History of psychotropic drug use. Severe obstetric complications, including preeclampsia, eclampsia, gestational hypertension, intracranial hypertension, hyperthyroidism, placenta previa. Intraoperative complications involving severe blood loss (>1000ml), combined organ injuries (intestinal or urinary system injuries). Allergy to NMDA receptor antagonists or dexmedetomidine. Change of anesthesia method ( conversion to general anesthesia). Heart rate below 50 beats per minute or presence of cardiac conduction block or arrhythmia, such as sick sinoatrial node syndrome. Preoperative hypotension (defined as systolic blood pressure < 90mmHg). Refusal to use the postoperative analgesic pump. Individuals unwilling to participate in questionnaire surveys and clinical examinations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidenceof positive PPD screening results; | — |
Countries
China
Contacts
Public ContactXu Zhendong
Department of Anesthesiology, the First Maternity and Infant Hospital Affiliated to Tongji University
Outcome results
None listed