Infertility
Conditions
Interventions
Treatment group -PRP group:After excluding contraindications, 20ml of peripheral venous blood was extracted from the patient to make platelet-rich plasma (PRP).The prepared PRP was injected into the u
Treatment group -PEVs group:After excluding contraindications, 20ml of peripheral venous blood was extracted from the patient to make extracellular platelet vesicles (PEVs).The prepared PEVs was injec
Experimental group - endometrial injury group:Lymphocyte infiltration and secretion of inflammatory factors were detected by taking part of endometrial tissue during operation
Experimental group - normal endometrium group:Lymphocyte infiltration and secretion of inflammatory factors were detected by taking part of endometrial tissue during operation
Sponsors
The Second Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Treatment group: 20~40 years old patients with thin endometrium who were admitted to the outpatient clinic of the Reproductive Medicine Center of the Second Affiliated Hospital of Soochow University, had no contraceptive measures and had regular sexual life for at least 1 year, and the thickness of the endometrium during ovulation was still <7mm during ovulation supplemented with sufficient estrogen, and there were no other infertility factors such as pelvis, endocrine and man, and there were normal ovulation in the past, and ovulation was monitored regularly under ultrasound, a total of 80 cases. According to the randomization method, they were divided into PRP group and PEVs group. 2. Experimental group: 20 patients aged 20~40 years old who were admitted to the Reproductive Medicine Center of the Second Affiliated Hospital of Soochow University, who had no contraceptive measures and had no pregnancy for at least 1 year. According to the medical history, they were divided into: (1) endometrial injury group: patients who were to undergo hysteroscopic surgery in our hospital due to endometrial injury diseases, such as moderate to severe intrauterine adhesions, thin endometrium, Achmann's syndrome, etc., and those who did not have other infertility factors such as pelvis, endocrine and male side. (2) Normal endometrial group: patients who intend to undergo laparoscopic combined hysteroscopic surgery in our hospital due to non-endometrial injury, such as fallopian tube obstruction, pelvic adhesions, etc., without other infertility factors such as endocrine and male partners.
Exclusion criteria
Exclusion criteria: 1. Congenital or acquired lesions of the reproductive system, such as anatomical abnormalities of the cervix, uterine fibroids, uterine malformations, endometrial tuberculosis, endometrial malignant lesions, etc.; 2. Patients with severe immune system and coagulation system diseases; 3. Patients with chromosomal abnormalities or unexplained infertility in either spouse; 4. Patients with endocrine abnormalities such as premature ovarian failure and hyperprolactinemia; 5. Male infertility factors such as male azoospermia, moderate to severe oligoasthenospermia; 6. Patients with severe primary organic lesions of heart, lung, liver, kidney and other important organs; 7. Patients with hormone-dependent malignant tumors; 8. People with mental illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Endometrial thickness;Endometrial type;Subendometrial blood flow classification;Biochemical pregnancy;Follicle size; | — |
Countries
China
Contacts
Public ContactZhang Hong
The Second Affiliated Hospital of Soochow University
Outcome results
None listed