Sepsis results from an abdominal infection
Conditions
Interventions
Oxycodone group:1.5 mg/kg oxycodone was diluted in normal saline to 50 ml and continuously pumped at 0.03-0.06 mg/kg/h (1-2 ml/h) .
Rufentanil group:50ug/kg remifentanil diluted to 50ml with saline, infused at 1.0-2.0ug/kgh (1-2ml/h).
Sponsors
Xuzhou Medical University Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age 18 or older 2. Patients with sepsis due to gastrointestinal perforation and treated surgically, and then admitted to the ICU and mechanically ventilated postatively. 3.Indications for analgesia and sedation 4. ASA grade I-III 5. Those who agree to participate in the trial and sign the informed consent form
Exclusion criteria
Exclusion criteria: 1. History of dependence on psychotropic drugs and Alcohol 2. Severe cardiovascular and cerebrovascular diseases, kidney and liver diseases before onset 3. Intervention with other sedative or analgesic medications within 1 week before enrolment 4 . Suffering from schizophrenia, epilepsy, Parkinson's syndrome, myasthenia gravis 5. Dependence on opioids, allergies, contraindications to research drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intra-abdominal pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| C-reactive protein;Duration of mechanical ventilation;Incidence of other adverse events (dizziness, headache, drowsiness and other complications) .;Incidence of nausea and vomiting at 24 h after oxycodone/Remifentanil administration.;Plasma albumin;Length of stay in ICU;White blood cells;Neutrophil/lymphocyte;Liver and kidney function;Blood protein input.; | — |
Countries
China
Contacts
Public ContactZhao Wenjing
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed