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Influence of different doses of liposomal bupivacaine in thoracic paravertebral nerve block on the analgesic effect in patients undergoing video-assisted thoracoscopic lung surgery

Influence of different doses of liposomal bupivacaine in thoracic paravertebral nerve block on the analgesic effect in patients undergoing video-assisted thoracoscopic lung surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500102806
Enrollment
Unknown
Registered
2025-05-20
Start date
2025-05-27
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thoracoscopic lung surgery

Interventions

Ropivacaine group (Group R):Before the induction of general anesthesia, ultrasound-guided thoracic paravertebral nerve block was performed. Ropivacaine group: 66 mg of ropivacaine (20 ml, 0.33%) was i
Low-dose liposome bupivacaine group (LL group):Before the induction of general anesthesia, ultrasound-guided thoracic paravertebral nerve block was performed. Low-dose liposome bupivacaine group: 133
High-dose liposome bupivacaine group (HL group):Before induction of general anesthesia, ultrasound-guided thoracic paravertebral nerve block was performed. High-dose liposome bupivacaine group: 266 mg

Sponsors

The First Affiliated Hospital of Zhengzhou University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients aged 18-65 years with American Society of Anesthesiologists (ASA) physical status I or III scheduled for elective thoracoscopic partial lung resection under general anesthesia in the First Affiliated Hospital of Zhengzhou University from May 2025 to August 2025 were enrolled.

Exclusion criteria

Exclusion criteria: 1. previous chest surgery; 2. diagnosed mental illness; 3. have a history of drug or alcohol abuse; 4. body mass index (BMI) 30kg/m^2; 5. severe liver and kidney dysfunction; 6. coagulation disorders; 7. infection at the puncture site; 8. long-term use of chronic analgesic drugs; 9. spinal deformity; 10. difficulty in communication.

Design outcomes

Primary

MeasureTime frame
Resting and active NRS pain scores;

Secondary

MeasureTime frame
Cumulative consumption of opiates;Time to remove chest drain;Length of hospitalization;Moderate-to-severe pain;

Countries

China

Contacts

Public ContactWang Yanping

The First Affiliated Hospital of Zhengzhou University

282243756@qq.com+86 135 2685 7360

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026