locally advanced cervical cancer
Conditions
Interventions
Gold Standard:Pathological examination and imaging examination (CT/MRI)
Index test:ctDNA detection, single-cell sequencing of tissue and peripheral blood samples
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Female patients aged between 18 and 75 years old, with good general condition and an ECOG performance status score of = 70, indicating that the physical condition can tolerate the examinations and operations related to the study; 5.Voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with concurrent other malignant tumors; 2. Those with severe dysfunction of important organs such as the heart, liver and kidney; 3.Pregnant or lactating women; 4.Patients with mental illness or those unable to cooperate with the study; 5. Patients with pre-existing distant metastasis before treatment; 6.Cervical cancer with rare pathological types (such as neuroendocrine carcinoma, undifferentiated carcinoma, etc.).
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Quality of life assessment; | — |
Primary
| Measure | Time frame |
|---|---|
| ctDNA was used to detect changes in MRD concentration;Single-cell sequencing of tissue samples; | — |
Countries
China
Contacts
Public ContactZuo Yufang
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed