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To investigate the effects of different maintenance regimens of anesthesia on intracranial pressure, nausea and vomiting in patients undergoing microvascular decompression

Effects of dexmedetomidine, propofol and sevoflurane on intracranial pressure and postoperative nausea and vomiting in patients undergoing microvascular decompression via retrosigmoid sinus approach: a retrospective study

Status
Recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500102774
Enrollment
Unknown
Registered
2025-05-20
Start date
2024-02-09
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurovascular compression syndrome

Interventions

Gold Standard:The WHO Postoperative Nausea and V classification criteria were as follows: Grade I: No nausea or vomiting was noted
Grade II: No nausea at rest, slight nausea during exercise, and mild vomiting (1–2 times/d)
Grade III: Intermittent nausea and moderate vomiting (3–5 times/d) during rest
Grade IV:
Index test:optic nerve sheath diameter

Sponsors

Army Medical Center of PLA
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1?Microangiopathy was diagnosed by clinical symptoms, imaging and laboratory examination; 2?Microvascular decompression via retrosigmoid approach was performed; 3?Their age ranged from 18 to 80 years; 4?ASA?-?; 5?If the clinical data were complete, the patient's complete examination and medical history data could be collected;

Exclusion criteria

Exclusion criteria: 1?Combined with ophthalmic diseases (eye infection, glaucoma, cataract, blindness, etc.), history of ocular trauma, and history of increased intraocular pressure; 2?Combined with severe heart, liver, kidney, lung and other important organ dysfunction; 3?Patients with coagulation dysfunction; 4?Patients with a history of Postoperative Nausea and Vomiting and motion sickness; 5?Preoperative use within 24 h of nausea and vomiting drugs or corticosteroids; 6?Recently taking drugs that affect cerebrospinal fluid pressure, such as diuretics and glucocorticoids; 7?Obese (BMI>=35kg /m²); 8?Difficult intubation; 9?Cough occurred 3 minutes before each measurement time point, and the peak intraoperative airway pressure was more than 30 cmH2O; 10?Patients who used neostigmine during perioperative period;

Design outcomes

Primary

MeasureTime frame
Optic nerve sheath diameter;postoperative nausea and vomiting;

Secondary

MeasureTime frame
headache;mean arterial pressure;

Countries

China

Contacts

Public ContactHu Yi

Army Medical Center of PLA

huyi921@sina.com+86 23 68729729

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026