Hypertension with aortic stenosis
Conditions
Interventions
Calcium channel blocker group:Amlodipine use
Renin-angiotensin system inhibitor group:Sacubitril-valsartan use
Sponsors
Guabgzhou First People‘s Hospital
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Voluntary cooperation with the study plan and agreement of informed consent; 2.Age >= 40 years; 3.Aortic stenosis; 4.Clinical blood pressure or 24-hour ambulatory blood pressure >=130/80 mmHg; 5.Not receiving aortic valve replacement surgery;
Exclusion criteria
Exclusion criteria: 1.Acute myocarditis, acute pericarditis, acute heart failure; 2.Obstructive hypertrophic cardiomyopathy and other left ventricular outflow tract obstruction causing severe hemodynamic disturbance; 3.History of hemorrhagic stroke or other major internal bleeding; 4.Successful resuscitation of severe ventricular arrhythmia, cardiogenic syncope and sudden cardiac death; 5.Alanine aminotransferase (ALT) or Aspartate aminotransferase (AST) were higher than 3 times the upper limit of normal value; 6.Serum creatinine >= 265 µmol/L; 7.Serum potassium >= 5.5 mmol/L; 8.Bilateral renal artery stenosis; 9.Irritating cough, angioedema and other RASI-intolerent symptoms after medication; 10.Pregnant or lactating women; 11.Language disorders, mental disorders, mental illness unable to cooperate with the examination and treatment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression of existing valvular disease; | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting systolic blood pressure;Resting diastolic blood pressure;Tricuspid annular plane systolic excursion/pulmonary arterial systolic pressure;New-onset valvular disease; | — |
Countries
China
Contacts
Public ContactLiu Cheng
Guabgzhou First People‘s Hospital
Outcome results
None listed