intrabony pocket periodontal defects
Conditions
Interventions
Experimental group:implant bone powder and hPDLSCs/ECM composite in periodontal intrabony defect and cover with a biological membrane
Control group:implant bone powder in periodontal intrabony defect and cover with a biological membrane
Sponsors
The Third Affiliated Hospital of Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. The participant must sign an informed consent form, indicating that they have been fully briefed on the nature of the study and agree to participate. 2. Participants must be between 18 and 65 years old. 3. Participants must have at least one tooth site with a two-wall or three-wall bone defect caused by periodontitis (intrabony pocket greater than 3mm). 4. As determined by the researchers, the participant's condition should be suitable for flap surgery plus bone grafting, with no more than five tooth sites requiring bone grafting. 5. Researchers must assess that the affected teeth can be preserved for at least 3 to 5 years following treatment.
Exclusion criteria
Exclusion criteria: 1. Individuals whom the researchers judge to be unlikely to adhere to the study procedures. 2. Presence of uncontrollable pathological processes within the oral cavity. 3. Known or suspected malignant tumors. 4. History of radiation therapy to the head and neck area. 5. History of chemotherapy within 5 years prior to the surgery. 6. Any systemic or local diseases, as determined by the researchers, that may affect post-operative healing. 7. Diagnosed with uncontrolled diabetes mellitus. 8. Use of steroids or other medications that could potentially impact post-operative healing. 9. Smoking more than 10 cigarettes per day. 10. Alcohol abuse or drug use. 11. Participation in other clinical studies simultaneously or within a few weeks prior to enrollment. 12. Pregnant women or those planning to become pregnant during the study period. 13. Ineligibility for Bone Grafting: Patients who do not meet the clinical conditions necessary for bone grafting. 14. Patients with severe periodontitis requiring bone grafting in more than five tooth sites.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bone-defect depth; | — |
Secondary
| Measure | Time frame |
|---|---|
| clinical attachment level;probing depth;bleeding on probing; | — |
Countries
China
Contacts
Public ContactJunjie Wu
The Third Affiliated Hospital of Air Force Medical University
Outcome results
None listed