nasopharyngeal carcinoma
Conditions
Interventions
Se supplement :oral supplement with Se capsule (360 µg/day) for two weeks before radiation and invervention untill the finish of irradiation.
Sponsors
The Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Nasopharyngeal carcinoma patients aged 18-70 years diagnosed by pathological biopsy; (2) Patients of Stage ?-?B according to the 8th edition of UICC/AJCC and received radical radiotherapy; (3) The ECOG physical status score is 0-2; (4) No usage of antibiotics and/or immunosuppressors of patients before treatment; (5) Normal functions of organs such as liver and kidney of normal functiuons; (6) Volunteer to participate this clinical trial and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) The volunteer who use chemo-drugs like fluorouracil during radiotherapy; (2) The volunteer who has severe hypersensitivity to selenium or selenium-containing drugs; (3) The volunteer who has malignant tumors in other organs; (4) The volunteer who has other contraindications of chemoradiotherapy; (5) The volunteer who has oral ulcer; (6) The volunteer who has primary immunodeficiency diseases; (7) The volunteer who use health care products for a long time, especially selenium-rich health care products; (8) The volunteer who was pregnant or allergic.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| selenium level in blood;Glutathione peroxidase 1;Glutathione peroxidase 2;Glutathione peroxidase 3;Glutathione peroxidase 4;Thiodoxin reductase;T lymphocytes;B lymphocytes;Natural killer cells;NKT cells;?d T cells;Granulocytes; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood routine examination; | — |
Countries
China
Contacts
Public ContactHuang Jing
The Affiliated Hospital of Guangdong Medical University
Outcome results
None listed