Effects of Intradialytic Cycling Combined with Blood Flow Restriction Exercise on Maintenance Hemodialysis Patients: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500102741

Enrollment

Unknown

Registered

2025-05-19

Start date

2025-06-01

Completion date

Unknown

Last updated

2026-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Uremia

Interventions

IDC-BFR group:Intradialytic Cycling with Blood Flow Restriction

IDC group:Intradialytic Cycling

Control group:None

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1.Age >= 18 years old. 2.Duration of maintenance hemodialysis (MHD) >= 3 months. 3.Regular hemodialysis schedule of 3 sessions per week. 4.Able to read Chinese. 5.Normal cognitive function and ability to comprehend exercise instructions. 6.Able to walk independently. 7.No acute complications (e.g., acute infection, unstable angina, acute myocardial infarction, stroke, recent fracture, etc.).

Exclusion criteria

Exclusion criteria: 1.Regular exercise habits: Weekly structured aerobic exercise >= 150 minutes or at least one session >= 30 minutes of resistance training. 2.Exercise-related contraindications: Skeletal muscle or neuromuscular disorders rendering walking unsuitable/impossible. 3.Hemodynamic instability: Uncontrolled severe hypertension/hypotension (pre-dialysis systolic BP >= 180 mmHg and/or diastolic BP >= 105 mmHg and/or heart rate >= 120 bpm), symptomatic heart failure, or symptomatic arrhythmia. 4.Interdialytic weight gain: >= 4 kg between dialysis sessions. 5.Contraindications to BFR use: Significant coagulopathy, suspected/confirmed lower extremity deep vein thrombosis (DVT), history of peripheral vascular disease (PVD), marked lower extremity edema, or dermatological abnormalities. 6.Inadequate dialysis: Single-pool Kt/V (spKt/V) <1.2. 7.Vascular access issues: Presence of lower extremity deep venous catheter or arteriovenous fistula (AVF)..

Design outcomes

Primary

Measure	Time frame
A 6-minute walk test;	—

Secondary

Measure	Time frame
Physical Function;Health-related quality of life;Health-related quality of life;Cardiac output;Cardiac output;Longitudinal myocardial stress;	—

Countries

China

Contacts

Public ContactYing Huang

The First Affiliated Hospital of Soochow University

yvonne1228@163.com+86 138 6212 1552

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 15, 2026